Time: 14 minutes
Producer: TED Talks
Lisa Genova, PhD, a neuroscientist and the author of Still Alice, begins by discussing amyloid and the accumulation of amyloid plaques in the brain. She says that as the amount of the amyloid plaques grow a tipping point is reached and this is when Alzheimer's begins.
She believes that the cure for Alzheimer's will likely be the prevention or slowing down of the plaques before they reach the tipping point and cause Alzheimer's Disease. She says that our lifestyle can influence our accumulation of the amyloid plaques
The APOE4 gene variant is discussed and she says that our DNA alone does not determine whether or not we get Alzheimer's Disease.
She discusses the role of sleep and cardio vascular health, including blood pressure, diabetes and obesity in the prevention of Alzheimer's Disease.
She discusses the role of neuroplasticity and cognitive reserve and the protection against Alzheimer's even when the pathology of Alzheimer's is present. She explains how Alzheimer's is ultimately the result of losing synapses and the importance of adding synaptic connections. She mentions the Nun Study and the cases where some of the sisters had the Alzheimer's pathology but showed no signs of the disease in their behavior.
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Alzheimer's doesn't have to be your brain's destiny, says neuroscientist and author of "Still Alice," Lisa Genova. She shares the latest science investigating the disease — and some promising research on what each of us can do to build an Alzheimer's-resistant brain.
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